![\"Semen](\"https:\/\/web.archive.org\/web\/20230924170327im_\/https:\/\/creaconceptions.com\/blog\/wp-content\/uploads\/2017\/01\/Sperm-DNA-1.png\")
<\/p>\nAccording to WHO, Infertility is a condition where a couple is unable to conceive spontaneously despite having unprotected, regular sexual intercourse for more than a year. Infertility is a health problem affecting approximately 15% of all couples trying to conceive. In 20% of the couples, the main cause is solely male related (WHO 2000) which is a\u00a0major concern as it is a clinical challenge of increasing significance.<\/p>\n
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Over the past decade, male factor has become the leading cause of sub-fertility among couples seeking treatment with IVF. Therefore, semen analysis plays an important role in diagnosing the male factor. Semen possesses a smallest and physically active cell called \u201cthe sperm\u201d that is highly specialized for one simple function-\u00a0\u201cFertilization of the egg\u201d.<\/em>\u00a0Semen analysis provides a small work-up of sperm like sperm number, motility and morphology. These parameters indicate only the physical appearance of a spermatozoa.<\/p>\n Even if\u00a0all these parameters are\u00a0normal, there can still be some damage in the DNA material that is present inside the sperm head. Infertile men are shown to have significantly more sperm DNA damage compared to fertile men (Saleh et al., 2002) and the time for a\u00a0spontaneous pregnancy to happen is proved to be longer in couples where the male partner has\u00a0an increased amount of sperm with DNA damage.<\/p>\n DNA:<\/strong><\/p>\n DNA (Deoxyribo Nucleic Acid) is the strand present in chromosomes that help in fertilizing the eggs and initializing a\u00a0healthy embryo. When this strand separates or breaks into pieces, it basically causes the DAMAGE and this is commonly called as DNA fragmentation. This has been suggested as one of the causes for male sub-\u00a0fertility.<\/p>\n Sperm DNA Fragmentation:<\/strong><\/p>\n The Sperm DNA fragmentation\u00a0test measures the stability of the DNA in sperm and provides an estimate of the level of DNA damage in the sperm. Couples who have experienced recurrent miscarriages, or several unsuccessful treatment cycles, are recommended with this test, as it\u00a0can help to diagnose the levels of DNA fragmentation.<\/p>\n Very few men are offered sperm DNA integrity analysis during their fertility work-up and are therefore not aware of the problem. This, despite the fact that in 10-25% of men diagnosed with unexplained infertility, sperm DNA damage can at least partly explain their childlessness. DNA damage can increase with age, so a man in his 50\u2019s or 60\u2019s may have a higher percentage of sperm fragmentation than someone in his 20\u2019s. Other factors \u2014 such as exposure to various chemicals or toxic agents, excessive heat, chemotherapy, radiation, smoking, obesity, air pollution, nutritional deficiencies\u00a0and\u00a0diabetes can cause DNA damage.<\/p>\n However, there is good news! There\u00a0is\u00a0hope that antioxidant vitamins can help minimize the damage.<\/p>\n One of the treatment options for sperm DNA fragmentation test in male infertility is ICSI which remains the gold standard embryology procedure to tackle male infertility, but success lies in selection of normal efficient sperm prior to ART. Good sperms are selected & injected\u00a0into the oocytes within a few hours of ejaculation (or surgically retrieved sperms) which can commence a healthy pregnancy.<\/p>\n Sperm DNA integrity plays an important role in fertility and conception.<\/p>\n Questions are welcome at embryo@creaconceptions.com or Call +919884065356<\/p>\n","protected":false},"excerpt":{"rendered":" According to WHO, Infertility is a condition where a couple is unable to conceive spontaneously despite having unprotected, regular sexual intercourse for more than a year. Infertility is a health problem affecting approximately 15% of all couples trying to conceive. In 20% of the couples, the main cause is solely male related (WHO 2000) which… Continue reading Sperm DNA \u2013 Can it have any cues for infertility treatment?<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":22,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-29","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","entry"],"_links":{"self":[{"href":"https:\/\/creaconceptions.com\/blog\/wp-json\/wp\/v2\/posts\/29","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/creaconceptions.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/creaconceptions.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/creaconceptions.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/creaconceptions.com\/blog\/wp-json\/wp\/v2\/comments?post=29"}],"version-history":[{"count":1,"href":"https:\/\/creaconceptions.com\/blog\/wp-json\/wp\/v2\/posts\/29\/revisions"}],"predecessor-version":[{"id":30,"href":"https:\/\/creaconceptions.com\/blog\/wp-json\/wp\/v2\/posts\/29\/revisions\/30"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/creaconceptions.com\/blog\/wp-json\/wp\/v2\/media\/22"}],"wp:attachment":[{"href":"https:\/\/creaconceptions.com\/blog\/wp-json\/wp\/v2\/media?parent=29"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/creaconceptions.com\/blog\/wp-json\/wp\/v2\/categories?post=29"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/creaconceptions.com\/blog\/wp-json\/wp\/v2\/tags?post=29"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}![\"Infertility](\"https:\/\/web.archive.org\/web\/20230924170327im_\/https:\/\/creaconceptions.com\/blog\/wp-content\/uploads\/2017\/01\/Sperm-DNA-2-300x159.png\")
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